University of California, Riverside

Stem Cell Core Facility



Selected Publications:


Low, K., Wong, L. Y., Maldonado, M., Manjunath, C., Horner, C. B., Perez, M., … Nam, J. (2017). Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System. Stem Cell Reports, 8(5), 1329–1339.

Maldonado, M., Luu, R. J., Ico, G., Ospina, A., Myung, D., Shih, H. P., & Nam, J. (2017). Lineage- and developmental stage-specific mechanomodulation of induced pluripotent stem cell differentiation. Stem Cell Research & Therapy, 8(1), 216.

Nampe, D., Joshi, R., Keller, K., zur Nieden, N. I., & Tsutsui, H. (2017). Impact of fluidic agitation on human pluripotent stem cells in stirred suspension culture. Biotechnology and Bioengineering, 114(9), 2109–2120.

Sparks, N. R. L., Martinez, I. K. C., Soto, C. H., & zur Nieden, N. I. (2017). Low Osteogenic Yield in Human Pluripotent Stem Cells Associates with Differential Neural Crest Promoter Methylation. Stem Cells, 36(3), 349–362.

Weng, N. J.-H., & Talbot, P. (2017). The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells. Stem Cell Research, 23, 39–49.


Maricela Maldonado, Lauren Y. Wong, Cristina Echeverria, Gerardo Ico, Karen Low, Taylor Fujimoto, Jed K. Johnson, Jin Nam. The effect of electrospun substrate-mediated cell colony morphology on the self-renewal of human induced pluripotent stennm cells. Biomaterials 50 (2015) 10-19

Cipriano AF, Sallee A, Guan RG, Zhao ZY, Tayoba M, Sanchez J, Liu H.Investigation of magnesium-zinc-calcium alloys and bone stem cell response in direct culture.Acta Biomater. 2015 Jan 15;12:298-321


Yang X, Scott HA, Ardekani S, Williams M, Talbot P, Ghosh K. Aberrant cell and basement membrane architecture contribute to sidestream smoke-induced choroidal endothelial dysfunction. Invest Ophthalmol Vis Sci. Apr 8;55(5):3140-7

Keller KC, Rodrigues B, zur Nieden NI. Suspension culture of pluripotent stem cells: effect of shear on stem cell fate. Crit Rev Eukaryot Gene Expr. 24(1):1-13

McClelland Descalzo DL, Ehnes DD, zur Nieden NI. Stem cells for osteodegenerative diseases: current studies and future outlook. Regen Med. Mar;9(2):219-30

Guan, B. X., B. Bhanu, P. Talbot, S. Lin. Bio-driven cell region detection in human embryonic stem cell assay. IEEE/ACM Transactions on Computational Biology and Bioinformatics, Jan 2014; 11(3):604-611

Lin, S.C., Talbot, P. Stem Cells. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 4. Elsevier Inc., Academic Press, pp. 390–394

Talbot, P. N. zur Nieden, S. Lin, I. Martinez, B. Guan and B. Bhanu. Use of video bioinformatics tools in stem cell biology. In: Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology, Eds: S. Sahu and D. Casciano, John Wiley, West Sussex, United Kingdom. p 379-402

Sebaa M, Nguyen TY, Dhillon S, Garcia S, Liu H. The effect of poly (3, 4-ethylenedioxythiophene) (PEDOT) coating on magnesium degradation and cytocompatibility with hESCs for potential neural applications. J Biomed Mater Res A. Feb 23

Cipriano AF, De Howitt N, Gott SC, Miller C, Rao MP, Liu H. Bone Marrow stromal cell adhesion and morphology on micro-and sub-micropatterned titanium. J Biomed Nanotechnol Apr 10(4):660-8


Daniel Nampe and Hideaki Tsutsui. Engineered micromechanical cues affecting human pluripotent stem cell regulations and Fate. Journal of laboratory Automation (JALA)

Aaron F. Cipriano et al. In vitro degradation of four magnesium–zinc–strontium alloys and their cytocompatibility with human embryonic stem cells. J Mater Sci: Mater Med 24:989–1003

Thanh Yen Nguyen et al. An in vitro mechanism study on the proliferation and pluripotency of human embryonic stems cells in response to magnesium degradation. PLOS One, Vol8, Issue 10


Nicole zur Nieden et al. Embryonic stem cell test: stem cell use in predicting developmental cardiotoxicity and osteotoxicity. Methods in Molecular Biology, Volume 889, 2012, pp 147-179

Rachel Z. Behar,  et al. Adaptation of stem cells to 96-well plate assays: use of human embryonic and mouse neural stem cells in the MTT Assay. Current Protocols in Stem Cell Biology 1C.13.1-1C.13.21, Suppl 23

Jaclyn Lock et al. Nanophase hydroxyapatite and poly(lactide-co-glycolide) composites promote human mesenchymal stem cell adhesion and osteogenic differentiation in vitro. J Mater Sci: Mater Med 23:2543–2552

Vasundhra Bahla et al. Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reproductive Toxicology 34 p.529– 537

R. Z. Behar et al. A method for rapid dose–response screening of environmental chemicals using human embryonic stem cells. Journal of Pharmacological and Toxicological Methods.

Huawen Ding et al. NO–b-catenin crosstalk modulates primitive streak formation prior to embryonic stem cell osteogenic differentiation. Journal of Cell Science 125, 5564–5577

Laughing Bear Torrez et al. Derivation of Neural Progenitors and Retinal Pigment Epithelium from CommonMarmoset and Human Pluripotent Stem Cells.Stem Cells International, Vol. 2012



Lin S et al. Video bioinformatics analysis of human embryonic stem cell colony growth. J Vis Exp. May 20;(39)

Lin S et al. Comparison of the toxicity of smoke from conventional and harm reduction cigarettes using human embryonic stem cells.Toxicol Sci. Nov;118(1):202-12


Jiaxi Zhou et al. mTOR supports long-term self-renewal and supressess mesoderm and endoderm activities of human embryonic stem cells. PNAS

Lluis Quintana et al. Morphogenetic and regulatory mechanisms during developmental chondrogenesis: new paradigms for cartilage tissue engineering. Tissue Engineering: Part B, vol 15, No1

More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Facility Information

Stem Cell Core Facility
Next to 501A Keen Hall

in association with:
College of Natural and Agricultural Sciences
College Building North, floors 2 & 3

Tel: (951) 827-6555
Fax: (951) 827-4190

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